Synapse
⌘+K
Synapse
PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
December 8, 2025Blood

Regulation of ribosomal RNA synthesis in Acute Myeloid Leukemia

View Full Paper
Ask AI
Bookmark
Share

Authors

PHPutzer HungCACharles Antony

Discussion

Loading...

Member takes

Overview

Observations reveal increased ribosome biogenesis in AML, suggesting sensitivity to venetoclax-induced apoptosis.

Key Points

  • This research investigates the regulation of ribosomal RNA synthesis in acute myeloid leukemia (AML) and its implications on cell survival.
  • Examined rRNA synthesis across hematopoietic cell types
  • Utilized a FISH-Flow protocol for rRNA quantification
  • Generated HoxA9-ER mouse model for Pol1 degradation
  • Analyzed synergistic effects of dTAG treatment with Bcl-2 inhibitors
  • AML cells show elevated levels of nascent and mature rRNAs compared to normal cells
  • Pol1 degradation causes G1 arrest and monocytic differentiation
  • dTAG treatment with Bcl-2 inhibitors induces apoptosis in Pol1-degron cells
  • Higher rRNA synthesis correlates with less mature immunophenotypes in AML cells

Cite This Study

Hung et al. (2025) studied this question.

synapsesocial.com/papers/693624d74fa91c937236d112https://doi.org/10.1182/blood-2025-5001
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Investigating ribosome biogenesis in AML identifies MYB-binding protein 1A (MYBBP1A) as an essential regulator of leukemia cells2025
  2. 2Dynamics of Ribosomal RNA Transcription and Abundance in Normal and Leukemic Hematopoiesis2025
  3. 3Hypermethylation of the ribosomal DNA coding sequence and disordered transcription factor binding as hallmarks of acute myeloid leukemia2025
  4. 4Ribosome biogenesis and its regulation by the exportin, CSE1L, are targetable vulnerabilities in childhood and young adult Acute Myeloid Leukemia2025
  5. 5Pre-malignant extracellular matrix drives leukemia transformation through reprogramming of pre-leukemic stem cells2025