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August 2, 2025Open Access

Dynamics of Ribosomal RNA Transcription and Abundance in Normal and Leukemic Hematopoiesis

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Authors

ESEleanor I. SamsVFVictoria K FeistEGErin M Gray

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Overview

Profiling rRNA transcription reveals differences in abundance between normal and leukemic hematopoiesis, indicating cell-type specificity.

Key Points

  • Ribosomal RNA (rRNA) transcription is crucial for ribosome biogenesis and varies by cell type.
  • 26S rRNA was found in excess across all cell types, especially in normal myeloid lineage.
  • Leukemic progenitors exhibited significantly higher rRNA levels compared to normal cells.
  • Trends in rRNA transcription relate closely to rDNA accessibility around hematopoiesis contexts.

Cite This Study

Sams et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d03bfhttps://doi.org/10.1101/2025.08.01.668217
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Regulation of ribosomal RNA synthesis in Acute Myeloid Leukemia2025
  2. 2Hypermethylation of the ribosomal DNA coding sequence and disordered transcription factor binding as hallmarks of acute myeloid leukemia2025
  3. 3Dynamic Ribosomal RNA Methylation Regulates Translation in the Hematopoietic System and is Essential for Stem Cell Fitness2025
  4. 4Cell-cycle dynamics of nascent transcription and mature RNA accumulation are concordant in normal fibroblasts2025
  5. 5Single-cell profiling of long non-coding RNAs in the hematopoietic system2025