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December 8, 2025BloodOpen Access

Investigating ribosome biogenesis in AML identifies MYB-binding protein 1A (MYBBP1A) as an essential regulator of leukemia cells

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Authors

PTPhuong ToEAEmilie AlardLHLauren Harrison-Oakes

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Overview

Proteomic analysis reveals MYBBP1A as a key regulator of ribosome biogenesis and apoptosis in acute myeloid leukemia, suggesting new therapeutic avenues.

Key Points

  • MYBBP1A knockdown significantly enhances apoptosis in acute myeloid leukemia cells, highlighting its critical role in cell survival.
  • Proteomic profiles showed altered expression of proteins associated with the cell cycle and ribosome biogenesis in leukemia.
  • Transcription factor MYBBP1A influences downstream gene expression including components of the cell cycle program in AML.
  • Findings suggest that MYBBP1A's regulation of cell growth and differentiation may provide new therapeutic strategies for AML.

Cite This Study

To et al. (2025) studied this question.

synapsesocial.com/papers/69362f764fa91c937236e373https://doi.org/10.1182/blood-2025-990
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Regulation of ribosomal RNA synthesis in Acute Myeloid Leukemia2025
  2. 2Rbm5 sustains leukemia stem cells through a Myc-driven transcriptional circuitry2026
  3. 3DNA-proximal MYB phosphorylation is required for oncogenic transcription in acute myeloid leukemia2025
  4. 4Implicating a functional domain (SPOC) of RBM15 in the pathogenesis of RBM15::MKL1 fusion protein-induced acute megakaryoblastic leukemia2025
  5. 5The m5C-binding protein YB-1 modulates proteasome inhibitors resistance in multiple myeloma via epigenetic modification2025