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December 8, 2025BloodOpen Access

Ribosome biogenesis and its regulation by the exportin, CSE1L, are targetable vulnerabilities in childhood and young adult Acute Myeloid Leukemia

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Authors

ACAli CheginiCSChaitra SarathyFHFieke W. Hoff

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Overview

Observational analysis revealed CSE1L influences ribosome biogenesis and leukemic outcomes in young patients with acute myeloid leukemia, suggesting treatment vulnerabilities.

Key Points

  • CSE1L depletion reduced acute myeloid leukemia growth and viability, leading to cell death.
  • Knockdown of CSE1L impaired large ribosome subunit export and decreased protein synthesis in young AML cells.
  • Increased ribosome biogenesis was associated with poorer outcomes in young acute myeloid leukemia patients.
  • Nucleocytoplasmic transport pathways showed significant alterations in childhood AML compared to older adults.

Cite This Study

Chegini et al. (2025) studied this question.

synapsesocial.com/papers/69362f4b4fa91c937236d785https://doi.org/10.1182/blood-2025-1452
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  5. 5Age-associated non-mutational resistance in acute myeloid leukemia is driven by DNA damage-induced transcriptional heterogeneity2025