Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025BloodOpen Access

Clonal persistence and early cooperative mutations shape transformation in myelofibrosis

View Full Paper
Ask AI
Bookmark
Share

Authors

CFChristopher FamulareGLGiuseppe Gaetano LoscoccoADAndriy Derkach

Discussion

Loading...

Member takes

Overview

Observational analysis reveals clonal evolution and somatic mutations in myelofibrosis, suggesting new intervention strategies.

Key Points

  • Clonal evolution drives the transformation from chronic phase to myelofibrosis-accelerated or blast phase.
  • Oncogenic mutations in TP53 and RUNX1 are associated with high-risk clones present before transformation.
  • Analysis of 186 samples from individuals highlights the genomic complexity and mutational burden.
  • Findings support early profiling of somatic mutations and clonal architecture to improve treatment strategies.

Cite This Study

Famulare et al. (2025) studied this question.

synapsesocial.com/papers/69362f4b4fa91c937236d79ahttps://doi.org/10.1182/blood-2025-2046
View Full Paper
Ask AI
Bookmark
Share