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December 8, 2025Blood

A single-cell atlas of diagnostic bone marrow to uncover the origins of CML relapse following therapy cessation

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Authors

MYMengge YuXYXinyi YangFSFlorian Schmidt

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Overview

Single-cell RNA sequencing uncovers biomarkers and relapse mechanisms in leukemic stem cells, suggesting new treatment strategies for CML.

Key Points

  • The research aims to identify molecular signatures in leukemic stem cells that can predict relapse in CML post-therapy cessation.
  • Performed single-cell RNA sequencing on diagnostic bone marrow samples from CML patients
  • Analyzed cell transcriptional states and their association with clinical outcomes
  • Conducted gene set enrichment analysis and differential gene expression testing to identify relapse-related programs
  • Identified distinct relapse-fated leukemic stem cell subtypes with specific transcriptional signatures
  • Demonstrated significant transcriptional differences in LSCs between patients who relapsed and those who remained in remission
  • Highlighted potential biomarkers, including SPAG6 and PRSS21, for early relapse risk stratification

Cite This Study

Yu et al. (2025) studied this question.

synapsesocial.com/papers/693624d44fa91c937236cfe4https://doi.org/10.1182/blood-2025-74
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