What type of study is this?

This is a Pre-Registered Trial study.

What question did this study set out to answer?

This study aims to characterize the genomic profile and clonal evolution of p190 chronic myeloid leukemia during tyrosine kinase inhibitor therapy compared to p210 chronic myeloid leukemia.

December 8, 2025Blood

Molecular landscape and clonal evolution in minor versus major BCR::ABL1 chronic myeloid leukemia under tyrosine kinase inhibition : A Study from the french group fi-LMC

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Authors

BPBenjamin PodvinInserm SHSandrine HayetteHospices Civils de Lyon VCValérie CoiteuxCentre Hospitalier Universitaire de Lille

Discussion

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Implication

Comprehensive genomic profiling reveals clonal evolution and mutation patterns in p190 versus p210 chronic myeloid leukemia.

Key Points

This study aims to characterize the genomic profile and clonal evolution of p190 chronic myeloid leukemia during tyrosine kinase inhibitor therapy compared to p210 chronic myeloid leukemia.
Identified 42 patients with p190 chronic myeloid leukemia from the Fi-LMC cohort
Compared findings to an age-matched cohort of 42 p210 patients on Imatinib
Performed genomic profiling using high-throughput sequencing
Monitored variant allele frequency and mutations over time
Patients with p190 displayed higher mutation rates compared to p210
Lower white blood cell and platelet counts were observed in p190 patients
Genomic profiling found ASXL1 and DNMT3A mutations in p190 patients
Routine genetic testing may improve risk assessment and treatment strategies

Cite This Study

Podvin et al. (2025) studied this question.

synapsesocial.com/papers/693624d44fa91c937236cfe8 https://doi.org/10.1182/blood-2025-77

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Molecular landscape and clonal evolution in minor versus major BCR::ABL1 chronic myeloid leukemia under tyrosine kinase inhibition : A Study from the french group fi-LMC

Discussion

Member takes

Implication

Key Points

Cite This Study

Molecular landscape and clonal evolution in minor versus major BCR::ABL1 chronic myeloid leukemia under tyrosine kinase inhibition : A Study from the french group fi-LMC

Discussion

Member takes

Implication

Key Points

Cite This Study

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