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December 8, 2025Blood

Trends in mortality from multiple myeloma and diabetes mellitus in the United States: A retrospective analysis from 1999 to 2020

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Authors

RIRehan IshaqueMYMadhuri YalamanchiliRHRonald M. Harris

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Overview

Retrospective analysis found worsening mortality trends in multiple myeloma for diabetic males, indicating disparities by race.

Key Points

  • The aim is to evaluate mortality trends for multiple myeloma among diabetic patients from 1999 to 2020.
  • Retrospective analysis using ICD-10 codes to identify multiple myeloma deaths in diabetic patients.
  • Age-adjusted mortality rates (AAMR) were calculated and trends assessed by gender, race, and year.
  • Linear regression analysis was conducted to track changes in AAMR over time.
  • Total of 18411 deaths from multiple myeloma in diabetic patients from 1999 to 2020.
  • AAMR was higher among diabetic males (0.527 per 100,000) than females (0.280 per 100,000).
  • Increase in AAMR among diabetic males was significant (β = 0.0066, p < 0.001), but no change for females (β = -0.0008, p = 0.298).
  • African American diabetic patients had the highest AAMR (1.009), three times greater than Whites (0.317).
  • No significant mortality trend change in diabetic African Americans (p = 0.727), slight upward trend noted in diabetic Whites (p = 0.039).

Cite This Study

Ishaque et al. (2025) studied this question.

synapsesocial.com/papers/693624d44fa91c937236d053https://doi.org/10.1182/blood-2025-8132
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Trends in death from multiple myeloma with concomitant diabetes mellitus in the USA2025
  2. 2Trends in mortality from multiple myeloma in patients younger than 55 years of age in the United States: A retrospective analysis from 1999 to 20202025
  3. 3Trends in Acute Myeloid Leukemia mortality among patients with diabetes mellitus in the United States, 1999–2024: A CDC wonder database analysis2025
  4. 4Rising mortality trends in elderly multiple myeloma patients with hypertension: A CDC wonder database analysis (1999–2023)2025
  5. 5Trends and disparities in diabetes-associated cancer mortality in the United States, 1999–2020.2026