What question did this study set out to answer?

This research aims to understand the transition dynamics from adenoma to invasive colorectal cancer.

December 8, 2025Cancer Research

Abstract PR004: Multi-omic spatial analysis reveals reshaping of tumour-immune dynamics at the transition to invasive colorectal cancer

View Full Paper

Ask AI

Bookmark

Authors

CSChirine SakrInstitute of Cancer Research KBKonstantin BräutigamInstitute of Cancer Research MRManuel Rodriguez‐JustoUniversity College London Hospitals NHS Foundation Trust

Discussion

Member takes

Implication

Multi-omic analysis demonstrates reshaping of immune surveillance and gene expression in colorectal cancer progression, implicating immune dynamics in cancer prevention.

Key Points

This research aims to understand the transition dynamics from adenoma to invasive colorectal cancer.
Analyzed archival ca-in-ads from 40 patients using multi-omic approaches.
Performed spatial transcriptomics, T-cell receptor sequencing, and low-coverage whole genome sequencing.
Combined digital pathology with multiplex imaging techniques to assess immune cell distributions.
Identified significant copy number alterations in carcinoma compared to adenomas.
Observed a shift in T-cell composition specific to adenoma or carcinoma regions.
Revealed increased macrophage infiltration in invasive cancer regions.

Cite This Study

Sakr et al. (2025) studied this question.

synapsesocial.com/papers/693624ce4fa91c937236cf37 https://doi.org/10.1158/1538-7445.canevol25-pr004

View Full Paper

Ask AI

Bookmark

Implication

Multi-omic analysis demonstrates reshaping of immune surveillance and gene expression in colorectal cancer progression, implicating immune dynamics in cancer prevention.

Abstract PR004: Multi-omic spatial analysis reveals reshaping of tumour-immune dynamics at the transition to invasive colorectal cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

Abstract PR004: Multi-omic spatial analysis reveals reshaping of tumour-immune dynamics at the transition to invasive colorectal cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider