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September 10, 2025Cancer MedicineOpen Access

Integrated Single‐Cell RNA‐Seq Reveals Immunosuppressive Mechanisms of Treg Cell Differentiation and Tumor Microenvironment Interactions in Colorectal Cancer

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Authors

DLDongwei LiGuangzhou UniversityJLJingya LiuShandong University of Traditional Chinese MedicineLYLi YuFirst Affiliated Hospital of Guangdong Pharmaceutical University

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Implication

This analysis reveals immunosuppressive mechanisms of treg cells and tumor microenvironment interactions, highlighting their role in colorectal cancer progression.

Key Points

  • Treg cells enhance immunosuppression in low differentiated colorectal adenocarcinoma, leading to tumor progression.
  • Key ligand-receptor interactions, such as TGFβ1 + Treg with CD8 + T cells, drive functional impairments in antitumor immunity.
  • Single-cell rna sequencing data from GEO was integrated to uncover distinct cellular dynamics in colorectal cancer.
  • This research suggests that targeting Treg-mediated immunosuppression could be a vital strategy for therapy in CRC.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68c23abeb210217d647819e2https://doi.org/10.1002/cam4.71202
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Also Consider

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  1. 1Single-cell technology reveals the crosstalk between tumor cells and immune cells: driving immune signal transduction and inflammation-mediated cardiac dysfunction in the tumor microenvironment of colorectal cancer2025 · 7 citations
  2. 2Revisiting the immune microenvironment of human colorectal cancer in the era of single-cell and spatial omics2025
  3. 3Regulatory T Cells in Colon Cancer: Implications for Pathogenesis, Prognosis and Emerging Therapeutic Strategies2025 · 5 citations
  4. 4Single-cell RNA sequencing analysis reveals the heterogeneity and effect of TAMs in colorectal cancer2025
  5. 5Integrative single-cell and computational analysis reveals ligands modulating human gamma delta T cell phenotypes in colorectal cancer 93752025