September 10, 2025Cancer Research

Abstract P38: Spatial Profiling of Colorectal Cancer Extracellular Milieu Reveals Novel Axes of Immunosuppression and Inflammation

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Discussion

Systems biology approach reveals immunosuppressive and inflammatory mechanisms in colorectal cancer, suggesting new therapeutic targets.

This research discovered novel axes of immunosuppression and inflammation in colorectal cancer tumors.
Using Multiplexed Ion Beam Imaging, 65 protein markers were analyzed across 3,700 views from 250 tumors.
The CellExt method quantified extracellular protein distributions, revealing distinct immunosuppressive and inflammatory modalities.
Identified pathways could inform targeted therapeutic interventions for specific subsets of colorectal cancer patients.

Baskar et al. (2025) studied this question.

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