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August 25, 2025Open Access

Revisiting the immune microenvironment of human colorectal cancer in the era of single-cell and spatial omics

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Authors

SZShuai ZhangShanxi Agricultural UniversityQFQingfeng FuChinese PLA General HospitalXYXiao–Tong YuanRutgers, The State University of New Jersey

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Implication

This review demonstrates novel immune subsets in colorectal cancer, highlighting therapeutic implications for improved outcomes in patients.

Key Points

  • Novel immune cell subsets were identified in colorectal cancer, influencing therapeutic strategies.
  • Recent advancements using single-cell RNA sequencing provided insights into cellular heterogeneity in the tumor microenvironment.
  • Studies reveal that understanding the tumor microenvironment can enhance the effectiveness of immunotherapies.
  • Exploring spatial transcriptomics may lead to more precise treatments for colorectal cancer patients.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68af7b2a7567bf4f94ff33d5https://doi.org/10.22541/au.175613488.82145372/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cellular characteristics of the immune microenvironment of colorectal cancer and progress in immunotherapy research2025 · 2 citations
  2. 2Abstract P19: Profiling of Colorectal Cancer Tumor Microenvironment using Spatial Multi-Omics2025
  3. 3Single-cell technology reveals the crosstalk between tumor cells and immune cells: driving immune signal transduction and inflammation-mediated cardiac dysfunction in the tumor microenvironment of colorectal cancer2025 · 7 citations
  4. 4Comprehensive Immune Subtyping and Multi-Omics Profiling of the Tumor Microenvironment in Colorectal Cancer: Implications for Prognosis and Personalized Immunotherapy2025 · 2 citations
  5. 5Integrated Single‐Cell <scp>RNA</scp>‐Seq Reveals Immunosuppressive Mechanisms of Treg Cell Differentiation and Tumor Microenvironment Interactions in Colorectal Cancer2025 · 3 citations