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December 8, 2025International Journal of SurgeryOpen Access

Revealing the mechanism of chanling Gao in preventing and treating liver metastasis in colorectal cancer through integrated multi-omics and artificial intelligence

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Authors

LJLi JHSHaiqiao SunALAi-Ling Liang

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Overview

This research demonstrates an innovative diagnosis-prognosis model for colorectal cancer, utilizing AI and network pharmacology to reveal potential mechanisms of Chanling Gao treatment effects.

Key Points

  • The study aims to uncover mechanisms by which Chanling Gao prevents liver metastasis in colorectal cancer using an AI-based model.
  • Establish a diagnosis-prognosis model for colorectal cancer using AI and network pharmacology.
  • Construct an active ingredient-target network for Chanling Gao to elucidate therapeutic mechanisms.
  • Develop prognostic models through NMF clustering and machine learning techniques validated across cohorts.
  • Identified 248 targets linked to Chanling Gao's action against liver metastasis.
  • Two prognostic subtypes (C1 and C2) were found, with C1 showing better survival outcomes.
  • Developed a CLG risk score prognostic model validated for accuracy in survival prognosis across cohorts.

Cite This Study

J et al. (2025) studied this question.

synapsesocial.com/papers/693624ba4fa91c937236c880https://doi.org/10.1097/js9.0000000000004322
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