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September 10, 2025CancersOpen Access

Prognostic Factors in Colorectal Liver Metastases: An Exhaustive Review of the Literature and Future Prospectives

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Authors

MCMaria ConticchioÉUÉmilie UldryMHMartin Hübner

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Overview

This review highlights prognostic factors influencing colorectal liver metastases management, suggesting novel biomarkers for personalized therapy.

Key Points

  • Molecular profiling is critical in guiding treatment decisions, affecting long-term survival in patients with colorectal liver metastases.
  • Key findings show that RAS/BRAF mutations can predict resistance to anti-EGFR therapies while MSI-H status suggests responsiveness to immunotherapy.
  • Current guidelines advocate for a personalized approach, yet standardizing criteria for resectability remains a significant challenge.
  • Emerging tools like circulating tumor DNA and insights from the gut microbiome hold promise for improving risk stratification and treatment efficacy.

Cite This Study

Conticchio et al. (2025) studied this question.

synapsesocial.com/papers/68c23f1fb210217d64794cf2https://doi.org/10.3390/cancers17152539
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