Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 8, 2025Frontiers in OncologyOpen Access

Construction of a prognostic model for colorectal cancer liver metastasis based on single-cell transcriptomics and regulation of the MIF pathway

View Full Paper
Ask AI
Bookmark
Share

Authors

JCJianqiang CaoZHZhaobin HeHGHuijie Gao

Discussion

Loading...

Member takes

Overview

Model predicts survival outcomes based on MIF pathway interactions and gene expression in colorectal cancer patients.

Key Points

  • A prognostic model accurately predicts overall survival for colorectal cancer patients with liver metastasis.
  • Key gene expression changes were identified: increases in TPM2, RPS17, and TNNT1, alongside reduced SPINK4.
  • Single-cell transcriptomic data from multiple databases provided the foundation for model development.
  • The intensified interaction between MIF and its receptors may promote metastasis and tumor progression.

Cite This Study

Cao et al. (2025) studied this question.

synapsesocial.com/papers/68e6494525bc5bdb98713a6fhttps://doi.org/10.3389/fonc.2025.1588514
View Full Paper
Ask AI
Bookmark
Share