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December 8, 2025BMC PsychiatryOpen Access

Effectiveness of implementing family involvement on patient outcomes in individuals with psychotic disorders: a pragmatic cluster randomised controlled trial

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Authors

RPReidar PedersenJRJan Ivar RøssbergKHKristin Sverdvik Heiervang

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Overview

Pragmatic trial reveals family involvement improves mental health and quality of life for patients with psychotic disorders, suggesting a need for greater implementation.

Key Points

  • To assess the effectiveness of family interventions on patient outcomes in individuals with psychotic disorders.
  • Pragmatic cluster randomised controlled trial with 15 Community Mental Health Centre units.
  • Participants were allocated to implementation support program (ISP) with family interventions or treatment as usual (TAU).
  • Patients completed assessments at inclusion, 6 months, and 12 months.
  • Primary outcome assessed was interpersonal relationship difficulties measured by a specific scale.
  • Linear mixed-effects models analyzed change over time between groups.
  • No significant difference in primary outcome difficulties in interpersonal relationships at 12 months (Cohen’s d = -0.19, p = 0.2).
  • Intervention arm patients reported less perceived criticism from relatives (d = − 0.4, p = 0.01).
  • Intervention arm patients showed reduced difficulties in overall functioning (d = − 0.29, p = 0.01).

Cite This Study

Pedersen et al. (2025) studied this question.

synapsesocial.com/papers/693624a44fa91c937236c453https://doi.org/10.1186/s12888-025-07501-z
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Family-based psychosocial interventions and social functioning in schizophrenia: a retrospective cohort study of caregiver–patient dyadic outcomes2026
  2. 2A secondary exploratory study of associations between patient- and clinician-reported clinical outcomes and fidelity for four evidence-based psychosis treatments2025
  3. 3Effectiveness of Remote Family Education and Support Program for Parents of Adolescents With Eating Disorders Based on Interpersonal Psychotherapy: A Randomized Controlled Trial2025
  4. 4Examining the feasibility of a crisis-focused Cognitive Behaviour Therapy (CBT)–informed psychological intervention for inpatients experiencing psychosis (the CRISIS study): results from a pilot randomised controlled trial2025 · 2 citations
  5. 5The Effectiveness of a Social Skills Training Intervention Program for Family Members of Patients With Schizophrenia in Japan: A Pilot Study2026