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December 8, 2025Frontiers in MedicineOpen Access

Multifaceted mechanisms and targeted delivery of mesenchymal stem cell-derived exosomes in cardiovascular diseases: a translational medicine perspective

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Authors

ZLZongjun Liu

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Overview

Review demonstrates cardioprotective effects of MSC-derived exosomes in heart failure and atherosclerosis, suggesting new therapeutic strategies.

Key Points

  • This review aims to consolidate knowledge on the mechanisms and delivery of MSC-derived exosomes in cardiovascular diseases.
  • Analyzed therapeutic mechanisms of MSC-exosomes in cardiovascular conditions including myocardial infarction and heart failure.
  • Reviewed current preclinical studies along with innovative engineering delivery methods.
  • Explored functions such as angiogenesis promotion and inflammatory response inhibition.
  • MSC-exosomes exert cardioprotective effects by enhancing angiogenesis and reducing apoptosis.
  • Various cardiovascular indications were explored, encompassing myocardial ischemia and myocarditis.
  • Innovative delivery methods improve bioavailability and targeting of MSC-exosomes in treatments.

Cite This Study

Zongjun Liu (2025) studied this question.

synapsesocial.com/papers/693624a44fa91c937236c269https://doi.org/10.3389/fmed.2025.1729698
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