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September 11, 2025Frontiers in PharmacologyOpen Access

Therapeutic potential of human umbilical cord mesenchymal stem cell-derived exosomes in myocardial infarction: from molecular mechanisms to clinical translation-an update

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Authors

NDNianhui DingAffiliated Hospital of Southwest Medical UniversityZZZaiyong ZhengSouthwest Medical UniversityCZChunxiang ZhangSouthwest Medical University

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Implication

This review highlights cardioprotective effects of HUCMSC-derived exosomes in myocardial infarction, indicating novel therapeutic approaches.

Key Points

  • HUCMSC-derived exosomes significantly promote cardiac regeneration, demonstrating extensive cardioprotective effects.
  • Preclinical studies show these exosomes improve outcomes in myocardial infarction, highlighting their therapeutic potential.
  • Advanced engineering methods enhance the efficacy of HUCMSC-derived exosomes in targeting key MI processes.
  • Despite promising results, challenges in clinical translation must be addressed to maximize their therapeutic impact.

Cite This Study

Ding et al. (2025) studied this question.

synapsesocial.com/papers/68d41734713b0b5dfea63a44https://doi.org/10.3389/fphar.2025.1667140
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