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December 5, 2025Diabetes Care

Integrative Metabolomics of Targeted and Non-Targeted Analyses in T2D Progression

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Authors

JGJianhong GeSHSiyu HanMSMengya Shi

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Overview

Analysis identifies metabolic differences in prediabetes and T2D, suggesting fasting glucose impacts incidence and intervention strategies.

Key Points

  • Metabolomics identified key metabolic shifts from glucose metabolism to prediabetes and T2D.
  • Significant findings include early-stage incidence with energy metabolism and fasting glucose influencing T2D risk.
  • Linear mixed-effects models were utilized to assess relationships among metabolite changes and glycemic factors.
  • Stage-specific metabolic profiling could inform targeted diabetes prevention strategies and intervention approaches.

Cite This Study

Ge et al. (2025) studied this question.

synapsesocial.com/papers/6932313d8e51979591dcef37https://doi.org/10.2337/dc25-1707
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