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September 19, 2025Diabetes Obesity and Metabolism

Integrative metabolomic and proteomic analysis of diabetic kidney disease progression with younger‐onset type 2 diabetes

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Authors

RGResham L GurungHZHuili ZhengJTJensen C. C. Tan

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Overview

Prospective analysis shows lower branched-chain amino acids relate to DKD progression in younger patients, suggesting metabolic disruptions.

Key Points

  • Lower plasma levels of branched-chain amino acids associate with diabetic kidney disease progression.
  • Ninety-eight metabolites showed different expression levels between progressors and non-progressors of DKD.
  • Integrative metabolomic and proteomic analysis utilized sparse partial least squares discriminant analysis for data integration.
  • Findings underscore the importance of metabolic and apoptotic pathways in diabetic kidney disease progression.

Cite This Study

Gurung et al. (2025) studied this question.

synapsesocial.com/papers/68d437f0713b0b5dfea7738ehttps://doi.org/10.1111/dom.70153
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