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August 26, 2025Diabetes Care

Longitudinal Metabolic Trajectories in Diabetes Prevention Program Participants Reveal Subgroups With Varying Micro- and Macrovascular Complication Risks

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Authors

EKEmily KobayashiNLNathaniel J. LindenNCNicholas Chan

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Overview

Observational analysis identified distinct metabolic clusters in prediabetes, suggesting differing microvascular and macrovascular complication risks.

Key Points

  • Two-thirds of individuals with prediabetes maintain stable metabolic profiles with low complication rates.
  • Cohort analysis revealed 92% of insulin-resistant participants progressed to T2D and had high rates of retinopathy.
  • Analysis of clinical data utilized tensor decomposition and Gaussian mixture modeling to define the metabolic clusters.
  • Findings highlight the importance of early intervention in insulin-resistant or renal dysfunction trajectories to prevent T2D complications.

Cite This Study

Kobayashi et al. (2025) studied this question.

synapsesocial.com/papers/68af7c997567bf4f94ff453fhttps://doi.org/10.2337/dc25-0866
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Longitudinal metabolic trajectories in Diabetes Prevention Program participants reveal subgroups with varying micro and macrovascular complication risks2025
  2. 2Beyond Glucose—Rethinking Prediabetes for Precision Prevention2025 · 16 citations
  3. 3Integrative Metabolomics of Targeted and Non-Targeted Analyses in T2D Progression2025 · 3 citations
  4. 42335-P: Metabolomic Analysis Reveals That Prediabetes Subgroups Have Different Likelihoods of T2D Onset: A Definition, Etiology, and Function: Integration to Enhance T2D Treatment (DEFINE-T2D) Consortium Analysis2026
  5. 52983-LB: Trajectories of Risk Factors among Participants with Long-Duration Type 1 Diabetes2026