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December 5, 2025NutrientsOpen Access

Fish Oil Present in High-Fat Diet, Unlike Other Fats, Attenuates Oxidative Stress and Activates Autophagy in Murine Adipose Tissue

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Authors

KCKarolina CiesielskaJWJacek WilczakAPAdam Prostek

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Overview

Observational analysis reveals fish oil activates autophagy and reduces oxidative stress in adipose tissue of C57BL/6J mice, suggesting specific lipid sources matter.

Key Points

  • Fish oil specifically enhanced autophagy and reduced oxidative stress in murine adipose tissue.
  • Mice on high-fat diets showed different effects based on lipid sources, with fish oil leading to active autophagy.
  • Analysis conducted on C57BL/6J mice consuming various fats over a total of 27 weeks.
  • These findings indicate that lipid source can significantly influence metabolic effects in adipose tissue.

Cite This Study

Ciesielska et al. (2025) studied this question.

synapsesocial.com/papers/693231308e51979591dce8a2https://doi.org/10.3390/nu17233776
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A high-fat diet enriched with fish oil affects metabolic pathways in the hypothalamus of rats: a proteomic approach2025
  2. 2Antiobesity Efficacy of Marine Tapra Fish ( <i>Opisthopterus tardoore</i> ) Oil in High‐Fat Diet‐Induced Obese Mice by Activating Lipolysis and Suppressing Adipose Inflammation2025
  3. 3High fat diet enhances catalase loading into adipose tissue derived extracellular vesicles with limited effect on oxidative stress2025 · 6 citations
  4. 4The metabolic response to high fat intake depends on dietary fatty acid composition and sex2025
  5. 5Impact of olive oil and different animal fats on tissue lipid profiles of C57PL/6N mice fed non-atherogenic diet2025