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October 15, 2025Open Access

A high-fat diet enriched with fish oil affects metabolic pathways in the hypothalamus of rats: a proteomic approach

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Authors

ASAdriana Pereira de SouzaAPAmanda Paula PedrosoMAMaria Claudina Camargo de Andrade

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Overview

Proteomic analysis shows a high-fat fish oil diet alters metabolic pathways in the hypothalamus, suggesting potential health risks.

Key Points

  • Intake of a high-fat fish oil diet affects protein expression in rat hypothalamus, indicating metabolic alterations.
  • Twenty-nine proteins were significantly altered, with 15 down-regulated and 14 up-regulated, emphasizing dietary impacts.
  • Pathway-enrichment analysis linked proteins to carbohydrate metabolism and TCA cycle, highlighting metabolic consequences.
  • Long-term excess consumption of fish oil may lead to harmful effects in the hypothalamus, despite its known health benefits.

Cite This Study

Souza et al. (2025) studied this question.

synapsesocial.com/papers/68efbd16d61273c8652d7fc4https://doi.org/10.20935/acadnutr7929
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