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September 10, 2025Scientific ReportsOpen Access

High fat diet enhances catalase loading into adipose tissue derived extracellular vesicles with limited effect on oxidative stress

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Authors

IJInae JeongJLJuhwan LeeSPSoo-Jeung Park

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Overview

Observational analysis reveals changes in catalase loading in EVs from obese mice, suggesting potential implications for oxidative stress management.

Key Points

  • The high-fat diet led to increased loading of catalase into extracellular vesicles from adipose tissue, but not to improved antioxidant capacity.
  • EVs from high-fat diet-fed obese mice showed upregulated catalase but did not enhance cell protection against oxidative stress.
  • Analysis of antioxidant enzyme expression showed no significant effects from the high-fat diet in adipose tissue.
  • The study indicates that while EVs can transport antioxidants, their effectiveness in combating oxidative stress in liver cells may be limited.

Cite This Study

Jeong et al. (2025) studied this question.

synapsesocial.com/papers/68c24317b210217d647a5615https://doi.org/10.1038/s41598-025-15594-5
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