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December 5, 2025Therapeutic Advances in Medical OncologyOpen Access

Therapeutic opportunities in EBV-positive gastric cancer subtypes

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Authors

HAHasan Al-SattarRORichard OwenAJAmir Mashia Jaafari

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Overview

This review identifies EBV-positive gastric cancer subtypes, revealing therapeutic potential and suggesting improved prognosis through immune checkpoint inhibitors and antiviral agents.

Key Points

  • Immune checkpoint inhibitors show promise in subtypes of EBV-positive gastric cancer, enhancing overall prognosis.
  • Patients exhibiting high microsatellite instability and distinct tumour microenvironments respond better to tailored therapies.
  • Therapeutic options include antiviral agents to address Helicobacter pylori co-infection and address inflammatory stress.
  • Identifying ARID1A mutations and utilizing PARP inhibitors could offer new strategies for effective treatment in gastric cancer.

Cite This Study

Al-Sattar et al. (2025) studied this question.

synapsesocial.com/papers/693231308e51979591dce7c4https://doi.org/10.1177/17588359251396619
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