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August 5, 2025OncogeneOpen Access

MUC1-C auto-regulatory complex with EBNA1 is responsible for latent Epstein-Barr virus-associated gastric cancer progression

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Authors

HOHiroki OzawaYWYin WangHWHenry Withers

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Overview

Research shows MUC1-C upregulation drives gastric cancer progression in patients with EBV, suggesting clinical implications.

Key Points

  • MUC1-C forms an auto-regulatory complex with EBNA1 that promotes gastric cancer progression.
  • The complex increases DNA methyltransferase expression, enhancing DNA methylation and cancer cell proliferation.
  • MUC1-C is essential for maintaining EBV latency and supports stem cell characteristics linked to gastric cancers.
  • Targeting MUC1-C may switch EBV latency to its lytic phase, providing potential therapeutic avenues.

Cite This Study

Ozawa et al. (2025) studied this question.

synapsesocial.com/papers/689521d79f4f1c896c427a54https://doi.org/10.1038/s41388-025-03519-5
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