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September 10, 2025Modern PathologyOpen Access

Epstein-Barr Virus-associated gastric cancer: a histopathologic study with comprehensive molecular profiling

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Authors

VAValentina AngerilliJGJessica GasparelloACAntonio Collesei

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Overview

This histopathologic study reveals distinct features of Epstein-Barr virus-associated gastric cancer, suggesting potential biomarkers.

Key Points

  • EBV-associated gastric cancers exhibit unique histopathological and molecular features distinct from other gastric cancers.
  • A total of 35 primary cases were characterized, showing high expression of EBER and moderate/strong CLDN18 in 66% of cases.
  • Genomic and transcriptomic profiling identified predictive biomarkers including PIK3CA alterations in 41% of tumors.
  • The study emphasizes a unique immune microenvironment in EBV-associated gastric cancer, particularly in CLS histotype.

Cite This Study

Angerilli et al. (2025) studied this question.

synapsesocial.com/papers/68c23bd7b210217d64787309https://doi.org/10.1016/j.modpat.2025.100881
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