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November 30, 2025European Journal of NeurologyOpen Access

Clinical and Laboratory Predictors of Poor Neurological Outcomes Following Infectious Encephalitis: Systematic Review and Meta‐Analysis

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Authors

TJThomas JohnsonMVMia VenablesBSBabak Soleimani

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Overview

Systematic review demonstrates key clinical factors affecting neurological outcomes in infectious encephalitis, suggesting important prognostic value.

Key Points

  • Poor neurological outcomes were linked to status epilepticus in infectious encephalitis patients, indicating significant clinical implications.
  • Infectious encephalitis outcomes were worse with elevated CSF protein levels, highlighting the importance of laboratory tests.
  • Observational studies revealed the prognostic value of clinical factors like Glasgow coma scale and immunocompromised status.
  • Findings support the need for further research on the impact of clinical and laboratory factors in predicting outcomes.

Cite This Study

Johnson et al. (2025) studied this question.

synapsesocial.com/papers/692b94581d383f2b2a378f48https://doi.org/10.1111/ene.70445
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Encephalitis: Predictive Role of Clinical and Diagnostic Data on Outcome—A Monocentric Study2025
  2. 2Neuroimaging for prognosis of central nervous system infections: a systematic review and meta-analysis2025
  3. 3Outcomes of Critically Ill Adult Patients With Acute Encephalitis2025
  4. 4Association of systemic inflammatory factors with clinical outcomes in patients with autoimmune encephalitis at different clinical stages2025
  5. 5Clinical Features and Outcomes in Adult Patients with Autoimmune Encephalitis Requiring Intensive Care: A Retrospective Cohort Study2025 · 2 citations