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December 8, 2025BloodOpen Access

Chronic myeloid leukemia (CML) evolution is not encoded in single-cell microstates, but emerges from population-level macrostates

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Authors

DFDavid FrankhouserZCZiang ChenJIJihyun Irizarry

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Overview

Modeling transcriptional dynamics shows distinct disease trajectories in chronic myeloid leukemia, suggesting novel insights into leukaemia evolution.

Key Points

  • To investigate the mechanisms underlying chronic myeloid leukemia (CML) progression and transformation potential.
  • Applied state-transition theory to model transcriptional dynamics of CML progression
  • Collected time-series scRNA-seq data from chronic phase and blastic phase CML mouse models
  • Performed differential gene expression analyses and compared sequential time points
  • Progression to chronic phase CML associated with decreases in B cells and increases in myeloid and stem cell populations
  • Significant transcriptional changes observed across major cell lineages during CML progression
  • Extended findings suggest disease trajectory only emerges when cells are aggregated into pseudobulk samples

Cite This Study

Frankhouser et al. (2025) studied this question.

synapsesocial.com/papers/693624d74fa91c937236d121https://doi.org/10.1182/blood-2025-5026
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