Time-lapse imaging reveals that alternating cell states enhance leukemia-initiation capacity in acute lymphoblastic leukemia, indicating key roles for MYC and BCL6.
Key Points
Autophagy levels modulate metabolic states in leukemia cells, influencing their growth and survival.
In engineered patient-derived B-ALL, alternating cell states showed a distinct functional role in leukemia initiation.
Time-lapse imaging tracked transitions between MYC and BCL6 states, demonstrating their opposing effects on cell mass accumulation.
Findings highlight potential therapeutic targets by revealing mechanisms of drug resistance and leukemia-initiating cell dynamics.