Design, synthesis, and cytotoxic evaluation of new thiosemicarbazone/thiazolidin-4-one derivatives on PC3 cells

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Cytotoxic evaluation identifies thiazolidin-4-one hybrids, suggesting they may enhance cancer treatment targeting androgen receptors.

Compound 9 showed potential as a selective androgen receptor-targeted anticancer agent, enhancing treatment strategies.
The results indicate promising anticancer agents, particularly in the case of thiazolidin-4-one-based hybrids, with potential applications.
The study utilized synthetic and computational approaches to optimize derivatives, focusing on their biological evaluation in PC3 cells.
Early findings support further optimization and development of thiazolidin-4-one compounds for anticancer therapies.

Tokalı et al. (2025) studied this question.

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