August 17, 2025Scientific ReportsOpen Access

Utility of 3-(2-oxo-2H-chromen-3-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde in the synthesis of novel 1,3,4-thiadiazoles or 1,3-thiazoles and study their cytotoxic activity

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Discussion

Synthesis of novel thiazoles and thiadiazoles shows cytotoxic activity against cancer cells, suggesting potential for new therapies.

Compounds exhibited up to 96% growth inhibition against cancer cells, indicating strong cytotoxicity.
The lead compound 6 demonstrated significant lethality against melanoma and renal cancer cells, with growth inhibition rates of 47.47% and 6.20%.
Observational analysis involved anticancer studies on 60 human cancer cell lines to assess efficacy.
Findings highlight the potential of coumarins linked to thiadiazoles and thiazoles for novel cancer treatments.

Abdel‐Aziem et al. (2025) studied this question.

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