October 9, 2025PharmaceuticalsOpen Access

Design and Optimization of Spiro-Isatin-Thiazolidinone Hybrids with Promising Anticancer Activity

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Discussion

Molecular docking reveals potent MDM2 inhibitors with improved cytotoxicity in cancer cells, suggesting viable therapeutic options.

Compound 18 exhibited potent anticancer activity, with an IC50 of 6.67–8.37 µM across cancer lines and >100 µM in normal cells.
Binding affinity for MDM2 was strong at −10.16 kcal/mol, indicating effective interaction compared to reference compounds.
Cytotoxicity was evaluated in vitro through MTT assays on diverse human and murine cancer cell lines and normal cells.
The derivatives demonstrated favorable ADMET properties, ensuring compliance with Lipinski’s Rule for good bioavailability.

Khyluk et al. (2025) studied this question.

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