Design, synthesis, biological assessment, and in silico analysis of bisthiazolidine amide derivatives as potential anti-bacterial and anti-prostate cancer agents

View Full Paper

Ask AI

Bookmark

Authors

Discussion

Assessment reveals antibacterial and anticancer activities in bisthiazolidine amide derivatives, indicating potential dual-use therapies.

M4 exhibited superior antibacterial effects against S. aureus with a MIC of 9.7 µg/mL, outperforming the standard drug cefixime.
Cytotoxicity assessments via MTT assays showed M4's IC50 of 19.56 µg/mL against PC3 cells, notably better than Darolutamide.
Molecular docking indicated possible EGFR inhibition, suggesting unique mechanisms of action for the derivatives.
The findings highlight promising compounds for developing dual-purpose therapeutic agents in cancer and bacterial infections.

Abbas et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark