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November 28, 2025FoodsOpen Access

Anti-Skin Aging Potential of Methoxyflavones from Kaempferia parviflora Against TNF-α-Induced Oxidative Stress and Photoaging in Normal Human Dermal Fibroblasts

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Authors

SASi Young AhnSJSe Yun JeongBLBum-Soo Lee

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Overview

Laboratory analysis shows methoxyflavones reduce MMP-1 in fibroblasts, indicating potential as anti-aging agents.

Key Points

  • Methoxyflavones suppressed TNF-α-induced reactive oxygen species generation, reducing oxidative stress.
  • Compounds 4 and 5 showed the strongest protective effects against MMP-1 in normal human dermal fibroblasts.
  • Assessment of biological activities was conducted using LC–MS analysis on five isolated methoxyflavones from black ginger.
  • These findings highlight methoxyflavones' potential as antioxidants in skincare, needing further validation in clinical studies.

Cite This Study

Ahn et al. (2025) studied this question.

synapsesocial.com/papers/6928f12ea65b730b9ea7a69chttps://doi.org/10.3390/foods14234012
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Also Consider

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  4. 4Codonopsis pilosula Lipophilic Extract-Loaded Thermosensitive Nanogel Attenuates Skin Photoaging by Inhibiting the FGFR/PI3K/AKT/mTOR Pathway2026
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