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July 19, 2026PharmaceuticsOpen Access

Codonopsis pilosula Lipophilic Extract-Loaded Thermosensitive Nanogel Attenuates Skin Photoaging by Inhibiting the FGFR/PI3K/AKT/mTOR Pathway

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Authors

JZJ H ZhouYGYuhui GeRLR K Li

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Overview

Randomized trial demonstrates improved skin health in UV-exposed models using a plant-based nanogel, suggesting effective anti-aging treatment.

Key Points

  • This research aims to evaluate the effects of a Codonopsis pilosula nanogel on skin photoaging induced by UV radiation.
  • Developed a thermosensitive nanogel encapsulating CP-L-loaded transferosomes.
  • Assessed effects in a UV-induced photoaging mouse model and UVB-irradiated keratinocytes.
  • Conducted transcriptomic and molecular analyses to examine signaling pathway inhibition.
  • Topical application reduced wrinkling and epidermal thickness by 83.2% in mice (p < 0.01).
  • Cell viability increased from 53.0% to 89.4% in HaCaT cells (p < 0.01), while apoptosis decreased from 30.1% to 12.4% (p < 0.01).
  • Inhibited the FGFR/PI3K/AKT/mTOR pathway, reducing phosphorylation levels of key proteins by up to 57.3% (p < 0.01).

Cite This Study

Zhou et al. (2026) studied this question.

synapsesocial.com/papers/6a5c69c3118b92953e3ee035https://doi.org/10.3390/pharmaceutics18070869
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