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June 20, 2026CosmeticsOpen Access

Cosmetic Anti-Aging Potential of the Traditional Thai Longevity Formula Mai-Kae-Den-Klong: Mechanistic Insights from Enzyme-Based Bioassays and In Silico Analysis

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Authors

TCTheeraphan ChumroenphatNWNattapong WongchumSSSurapon Saensouk

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Overview

Randomized trial shows promising anti-aging effects of Mai-Kae-Den-Klong in cosmetic applications, suggesting natural alternatives can enhance skin health.

Key Points

  • This study aims to explore the anti-aging potential of the traditional Thai herbal formula Mai-Kae-Den-Klong (MKDK) using enzyme bioassays and in silico analysis.
  • Investigated antioxidative and anti-aging properties of MKDK using enzyme-based bioassays and in silico methods.
  • Conducted LC-MS analysis for phytochemical profiling of MKDK extract.
  • Assessed inhibitory activities against skin-aging enzymes: tyrosinase, collagenase, elastase, and hyaluronidase.
  • MKDK extract showed strong antioxidant activity with IC50 values of 17.23 µg/mL (DPPH) and 11.87 µg/mL (ABTS).
  • Exhibited inhibitory effects with IC50 values: tyrosinase 41.25 µg/mL, elastase 49.51 µg/mL, collagenase 61.54 µg/mL, and hyaluronidase 63.74 µg/mL.
  • Molecular docking revealed favorable binding of key metabolites to skin-aging-related enzymes.

Cite This Study

Chumroenphat et al. (2026) studied this question.

synapsesocial.com/papers/6a362ebddb0793dc1a5365c8https://doi.org/10.3390/cosmetics13030158
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