The role of dynamic reciprocity in 3D cell migration: connecting cell and matrix mechanics to migratory plasticity

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Migratory cells exhibit mode-switching in 3D environments due to dynamic interactions with their microenvironments.
These interactions highlight the reciprocal effects between cell mechanics and the physical properties of the surrounding matrix.
Understanding these mechanisms could advance knowledge of eukaryotic cell motility and its implications for health.
The study emphasizes the cytoskeleton’s vital role in adapting to diverse physical environments to achieve mechanical homeostasis.

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This review highlights how dynamic reciprocity influences migratory plasticity in cells, suggesting a crucial link to cell mechanics.

Duggan et al. (2025) studied this question.

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