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November 25, 2025The Journal of ImmunologyOpen Access

Elevated proportion of circulating T effector memory cells is associated with early disease recurrence in oral squamous cell carcinoma – a case report 3958

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Authors

BBBrianna BrammerBKBrendan KinneyJGJennifer Gross

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Overview

Case report shows elevated T effector memory cells associate with disease recurrence in oral squamous cell carcinoma, suggesting risk factor implications.

Key Points

  • To identify predictive factors for early disease recurrence in oral squamous cell carcinoma.
  • Case report involving two patients with stage 4 OSCC and differing outcomes
  • Clinical evaluation of disease status and treatment history
  • Comparison of circulating T effector memory cells between the patients
  • Nearly half of OSCC patients experience disease recurrence within one year of treatment
  • The 53-year-old patient had 42.8% CD8+ HD TEMRA cells associated with poor outcomes
  • The 86-year-old patient with similar OSCC had only 0.23% CD8+ HD TEMRA cells and no recurrence

Cite This Study

Brammer et al. (2025) studied this question.

synapsesocial.com/papers/692502b787af00ed34ac213dhttps://doi.org/10.1093/jimmun/vkaf283.1699
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association of Age and Residual/ Recurrence in First Year after Treatment of Oral Cavity Squamous Cell Carcinoma2025
  2. 2Determining the minimal necessary flow cytometry markers to identify prognostic TEMRA cell population in head and neck squamous cell carcinoma 39712025
  3. 3Prognosis of second primary oral squamous cell carcinoma after hematologic malignancy: a retrospective cohort analysis2025
  4. 4Demographic Profile of Oral Squamous Cell Carcinoma Patients Treated with Radiation Therapy: A Retrospective Observational Study at a Johannesburg Academic Hospital (2014–2019), South Africa2025
  5. 5Prognostic Value of the Immunohistochemical Detection of Cellular Components of the Tumor Microenvironment in Oral Squamous Cell Carcinoma: A Systematic Review2025 · 3 citations