Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 14, 2025Current Issues in Molecular BiologyOpen Access

Prognostic Value of the Immunohistochemical Detection of Cellular Components of the Tumor Microenvironment in Oral Squamous Cell Carcinoma: A Systematic Review

View Full Paper
Ask AI
Bookmark
Share

Authors

HMHannah Gil de Farias MoraisCCCaroline Fernandes da CostaMMMaurília Raquel de Souto Medeiros

Discussion

Loading...

Member takes

Overview

Systematic review finds tumor microenvironment impacts survival in oral squamous cell carcinoma, highlighting potential prognostic markers.

Key Points

  • The review assesses the prognostic impact of tumor microenvironment components in oral squamous cell carcinoma.
  • 59 articles identified key cellular components like cancer-associated fibroblasts and immune cells affecting prognosis.
  • Presence of α-SMA-positive CAFs and tumor-associated macrophages correlates with poor outcomes in OSCC.
  • High amounts of NK CD57+ and CD8+/CD45RO+ T cells relate to better survival rates, marking them as promising prognostic tools.

Cite This Study

Morais et al. (2025) studied this question.

synapsesocial.com/papers/689a02b6e6551bb0af8cc2c6https://doi.org/10.3390/cimb47070544
View Full Paper
Ask AI
Bookmark
Share