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September 10, 2025Frontiers in OncologyOpen Access

Prognosis of second primary oral squamous cell carcinoma after hematologic malignancy: a retrospective cohort analysis

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Authors

HYHuajiao YuBLBo LiYHYu Huang

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Overview

Retrospective cohort analysis reveals no significant survival differences in patients with oral cancer histories, suggesting unchanged treatment strategies.

Key Points

  • No significant survival differences were found between second primary oral squamous cell carcinoma and primary OSCC groups.
  • Cox regression showed age, T stage, and N stage as independent predictors of survival, while prior hematologic malignancy was not.
  • The analysis included 14 patients with second primary malignancies, indicating treatment methods need no modifications.
  • Despite cohort adjustments using propensity score matching, prognosis based on HM history shows no independent effect.

Cite This Study

Yu et al. (2025) studied this question.

synapsesocial.com/papers/68c23b4ab210217d64783e2fhttps://doi.org/10.3389/fonc.2025.1667226
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prognostic Disparities in Multiple versus Single Primary OSCC: A Large-Cohort Analysis and Predictive Modelling2026
  2. 2Second primary malignancies in multiple myeloma: Incidence, survival and prognostic factors from a large single-center observational study2025
  3. 3Second Primary Malignancy in Multiple Myeloma: a retrospective monocentric analysis of Department of Hematology of the Oncologic Hospital from Cagliari2025
  4. 4Comparative Analysis of Primary and Second Primary Multiple Myeloma: A Propensity Score-Matched Study.2025
  5. 5Elevated proportion of circulating T effector memory cells is associated with early disease recurrence in oral squamous cell carcinoma – a case report 39582025