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October 27, 2025Open Access

From Metabolic to Epigenetic Memory: The Impact of Hyperglycemia-Induced Epigenetic Signature on Kidney Disease Progression and Complications

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Authors

SCSara CannitoIGIda GiardinoMDMaria D’Apolito

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Overview

This review uncovers how hyperglycemia and epigenetic alterations drive renal injury in diabetes, suggesting new biomarkers and therapies.

Key Points

  • Chronic kidney disease progression is driven by hyperglycemia, which causes renal injury and increases complications.
  • Key epigenetic mechanisms include DNA methylation and histone modifications affecting kidney health long-term.
  • Findings suggest targeting epigenetic biomarkers may offer new strategies for managing diabetes-related kidney disease.
  • This highlights the role of metabolic memory in sustaining renal damage, calling for precision medicine approaches.

Cite This Study

Cannito et al. (2025) studied this question.

synapsesocial.com/papers/68ff87e9c8c50a61f2bdd25fhttps://doi.org/10.20944/preprints202510.1919.v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1From Metabolic to Epigenetic Memory: The Impact of Hyperglycemia-Induced Epigenetic Signature on Kidney Disease Progression and Complications2025
  2. 2Advances in the Epigenetic Mechanisms of Diabetic Nephropathy Pathogenesis2025
  3. 3The Impact of Epigenomics on Understanding Kidney Diseases2025
  4. 4Role of Nuclear Receptors, Lipid Metabolism, and Mitochondrial Function in the Pathogenesis of Diabetic Kidney Disease2025 · 19 citations
  5. 5Epigenetic memories induced by hypoxia in AKI-to-CKD transition2025