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October 23, 2025BMC ImmunologyOpen Access

Single-cell transcriptomics of cervical lymph node tuberculosis reveals cellular heterogeneity and enhanced cellular communication

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Authors

GXGuohui XiaoHWHaijiang WangSZSu Zhang

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Overview

Single-cell RNA sequencing reveals enhanced cellular communication and pro-inflammatory pathways in cervical lymph nodes infected with Mtb, indicating a complex immune response.

Key Points

  • The immune dynamics in cervical lymph nodes show extensive upregulation of pro-inflammatory pathways, highlighting the role of transcriptional reprogramming.
  • Single-cell RNA sequencing identified specific alterations in macrophages and T cells involved in cellular communication during Mtb infection.
  • Using computational network modeling and flow cytometry, a detailed analysis mapped immune cell heterogeneity across T, B, and myeloid subsets.
  • These findings provide valuable insights for developing therapies that target intercellular networks to balance immunity and pathological effects in tuberculosis.

Cite This Study

Xiao et al. (2025) studied this question.

synapsesocial.com/papers/68fa32a40df2e6cd2f74205chttps://doi.org/10.1186/s12865-025-00763-y
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Also Consider

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  1. 1Single-cell profiling of blood and cerebrospinal fluid in tuberculous meningitis2025
  2. 2Single-cell transcriptomic profiling reveals a novel signature of necrotizing granulomatous lesions in the lungs of Mycobacterium tuberculosis-infected C3HeB/FeJ mice2025
  3. 3Spatial transcriptomic analysis of chronic lymphocytic leukemia lymph nodes reveals tumor microenvironment evolution during disease progression2025
  4. 4Functional and phenotypic characterization of peripheral blood mononuclear cells from tuberculosis patients in Southern Thailand2025 · 2 citations
  5. 5NK cell-macrophage interactions in granulomas correlate with limited tuberculosis pathology2025