August 14, 2025The Journal of ImmunologyOpen Access

Single-cell profiling of blood and cerebrospinal fluid in tuberculous meningitis

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Single-cell RNA sequencing analyzes CSF and blood cell types in tuberculous meningitis, suggesting new treatment targets.

CSF showed increased inflammatory microglia-like macrophages and reduced cytotoxicity in T and NK cells compared to blood.
Among 29 identified cell subtypes, significant variation in relative abundance was observed between CSF and blood samples.
Single-cell RNA sequencing helped clarify immunopathogenic mechanisms in TBM, emphasizing pathways for future research.
Findings underscore the potential for developing improved therapies targeting specific immune cell populations in TBM.

Tram et al. (2025) studied this question.

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August 14, 2025The Journal of ImmunologyOpen Access

View Full Paper

Ask AI

Bookmark

Authors

Single-cell RNA sequencing analyzes CSF and blood cell types in tuberculous meningitis, suggesting new treatment targets.

CSF showed increased inflammatory microglia-like macrophages and reduced cytotoxicity in T and NK cells compared to blood.
Among 29 identified cell subtypes, significant variation in relative abundance was observed between CSF and blood samples.
Single-cell RNA sequencing helped clarify immunopathogenic mechanisms in TBM, emphasizing pathways for future research.
Findings underscore the potential for developing improved therapies targeting specific immune cell populations in TBM.

Tram et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark