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October 8, 2025Frontiers in ImmunologyOpen Access

Functional and phenotypic characterization of peripheral blood mononuclear cells from tuberculosis patients in Southern Thailand

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Authors

POPyae Sone OoJOJomkwan OngarjRSRatchanon Sophonmanee

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Overview

This study compares immune responses in patients with active TB and latent TB infection, revealing key differences. It highlights the role of immune cells in potential TB diagnostics and treatment.

Key Points

  • MGIA showed enhanced control of BCG growth in active TB patients versus latent TB and healthy controls.
  • NK cell frequency and TNF-α levels were higher in active TB compared to latent TB and healthy controls.
  • Functional and phenotypic analysis of PBMCs was conducted using flow cytometry among different patient groups.
  • These findings suggest potential biomarkers for TB diagnosis and may assist in tailoring vaccine strategies.

Cite This Study

Oo et al. (2025) studied this question.

synapsesocial.com/papers/68e6679587ecc93a24d1760dhttps://doi.org/10.3389/fimmu.2025.1639808
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