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October 23, 2025Molecular OncologyOpen Access

Aggressive prostate cancer is associated with pericyte dysfunction

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Authors

AMAnabel Martínez-RomeroAMAne Martinez‐LarrinagaJGJoaquím Grego‐Bessa

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Overview

Analysis of pericyte dysfunction shows altered endothelial balance in prostate cancer, indicating vascular changes may affect disease progression.

Key Points

  • Prostate cancer exhibited a disequilibrium between endothelial content and pericyte dysfunction, suggesting altered vascular dynamics.
  • Single-cell RNA sequencing revealed key molecular changes related to pericyte function in tumors, with implications for cancer progression.
  • The study identifies TGF-β as a regulator influencing pericyte dysfunction, increasing vascular permeability during cancer.
  • Findings challenge traditional views on pericyte numbers, emphasizing the significance of their functional changes in cancer.

Cite This Study

Martínez-Romero et al. (2025) studied this question.

synapsesocial.com/papers/68f9d6583f378872224924dahttps://doi.org/10.1002/1878-0261.70135
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  5. 5Pericytes and Lung Vascular Remodeling2025