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August 8, 2025

Insight into pericytes in glioblastoma angiogenesis: In vivo tracking by two-photon microscopy and proteomic profiling.

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Authors

QWQinghong WangJiangsu Normal UniversityCMChengyan MaNorthwestern Polytechnical UniversityXWXinpei WangSouthwest University

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Implication

Investigations reveal pericytes enhance angiogenesis in glioblastoma, indicating potential therapeutic targets.

Key Points

  • Core finding shows pericytes are crucial for glioblastoma angiogenesis, indicating their role in tumor progression.
  • Tracking pericyte dynamics reveals that early ablation slows tumor growth, while late ablation accelerates it.
  • Two-photon microscopy and proteomics helped visualize pericyte behavior and analyze protein changes in glioblastoma.
  • Discovering altered proliferation pathways in pericytes suggests new therapeutic targets for glioblastoma treatment.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/689dfe97d61984b91e13be5fhttps://doi.org/10.1002/ame2.70073
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