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December 8, 2025Arteriosclerosis Thrombosis and Vascular Biology

Pericytes and Lung Vascular Remodeling

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Authors

MMM. Elizabeth MossMSMarisa C SmitTKTimothy Klouda

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Implication

Review discusses pericytes' role in pulmonary hypertension, highlighting mechanisms of vascular remodeling and plasticity.

Key Points

  • To explore the contributions of pericytes to vascular remodeling in pulmonary hypertension.
  • Review of historical and recent insights into pericyte morphology and function.
  • Analysis of emerging evidence regarding pericyte roles in vascular diseases and pulmonary hypertension.
  • Examination of novel pericyte identification methods, including single-cell RNA sequencing.
  • Identified pericytes as key players in vascular remodeling processes in pulmonary hypertension.
  • Highlighted the impact of plasticity and phenotypic switching of pericytes on vascular health.
  • Revealed the roles of hypoxia signaling and transforming growth factor-β in pericyte function.

Cite This Study

Moss et al. (2025) studied this question.

synapsesocial.com/papers/693624ad4fa91c937236c587https://doi.org/10.1161/atvbaha.125.322518
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