Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 25, 2025Physiological Reviews

Angiocrine and Pericrine Signaling: How Endothelial Cells and Pericytes Drive Cancer Progression and Therapy Resistance

View Full Paper
Ask AI
Bookmark
Share

Authors

AJAlexander JordanRDRebecca J.G. DrakeKHKairbaan Hodivala‐Dilke

Discussion

Loading...

Member takes

Overview

This review highlights angiocrine and pericrine signaling roles in cancer and therapy resistance, indicating novel therapeutic targets.

Key Points

  • MAIN FINDING: Endothelial and pericyte signaling are crucial in regulating cancer growth and therapy resistance.
  • KEY EVIDENCE: Research shows that these signals influence metastasis, immune responses, and tumor microenvironment dynamics.
  • APPROACH: The review summarizes existing studies on angiocrine and pericrine signaling in cancer treatment strategies.
  • SIGNIFICANCE: Understanding these interactions can lead to the development of innovative cancer therapies targeting these pathways.

Cite This Study

Jordan et al. (2025) studied this question.

synapsesocial.com/papers/689a0933e6551bb0af8ce322https://doi.org/10.1152/physrev.00046.2024
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Angiocrine Niche in Cancer Therapy Responses: The Role of Vascular Endothelial Cells in Immunomodulation2026
  2. 2Mechanisms of Tumor Angiogenesis and Resulting Therapy Resistance2025
  3. 3Aggressive prostate cancer is associated with pericyte dysfunction2025 · 2 citations
  4. 4Emerging Strategies for Targeting Angiogenesis and the Tumor Microenvironment in Gastrointestinal Malignancies: A Comprehensive Review2025 · 5 citations
  5. 5Pericytes promote metastasis by regulating tumor local vascular tone and hemodynamics2025 · 7 citations