Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025Molecular Medicine ReportsOpen Access

Mitophagy and oxidative stress in chronic kidney disease (Review)

View Full Paper
Ask AI
Bookmark
Share

Authors

QMQuwu MushuoJLJianchun LiQHQiongdan Hu

Discussion

Loading...

Member takes

Overview

Review demonstrates the role of mitophagy and oxidative stress in chronic kidney disease, suggesting therapeutic strategies for treatment.

Key Points

  • The review examines how impaired mitophagy and oxidative stress contribute to chronic kidney disease (CKD).
  • Analysis of molecular mechanisms of mitophagy
  • Focus on regulatory signaling pathways such as PTEN-induced kinase 1 and Parkin
  • Discussion of therapeutic strategies to enhance mitophagy and antioxidant capacity
  • Impaired mitophagy leads to increased oxidative stress in CKD
  • The interaction of mitochondrial dysfunction and inflammation promotes fibrosis
  • New therapeutic strategies may restore mitophagy and improve antioxidant defenses in CKD

Cite This Study

Mushuo et al. (2025) studied this question.

synapsesocial.com/papers/693624ba4fa91c937236c8bdhttps://doi.org/10.3892/mmr.2025.13771
View Full Paper
Ask AI
Bookmark
Share